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Emerging paradigms in exploring the interactions among diet, probiotics, and cancer immunotherapeutic response

Year: 2023
Type: article
Abstract: In the new issue of Cell, Dr. Meisel’s team characterized how the orally administrated probiotic bacteria Lactobacillus reuteri (Lr) translocated from the gut to tumors in mice with melanoma.1 Furthermore, its production of a compound called indole-3-aldehyde (I3A) derived from dietary tryptophan directly stimulates immune cells to make cancer immunotherapy more effective (Figure 1A). Here, we highlight and comment on the essential findings and provide our insights into the emerging research paradigm for future exploration of novel anti-tumor probiotics and underlying mechanisms.
DOI: 10.1016/j.xinn.2023.100456
Authors: Shi Huang, Chengyong He, Jiufeng Li, Yi-Zhou Gao, Zuoyun Wang, Yongjun Wei
Institutions: University of Hong Kong, Xiamen University, Fudan University, Chinese Academy of Sciences, Shanghai Medical College of Fudan University, Shanghai Xuhui Central Hospital, Zhengzhou University
Language: English
Subfield: Food Science
Open Access status: gold
Estimated APC paid: $3,000
Funders: Natural Science Foundation of Shanghai, National Natural Science Foundation of China, Youth Innovation Promotion Association of the Chinese Academy of Sciences, Health and Medical Research Fund, National Key Research and Development Program of China, Youth Innovation Promotion Association
Awards: G2474591673, G256755223, G2827810737, G3800309827, G4285368189, G4630746245, G4829338457, G5464788322, Discovering Microbial Features for Oral Cancer Diagnosis and Prediction, G8138343523, G8750011046
OpenAlex ID: W4379207993
FWCI: 2.71
Cites: 5
Cited by: 21
Related to: 10