Work

Intrapulmonary arterial contraction assay reveals region-specific deregulation of vasoreactivity to lung injuries

Year: 2023

Type: article

Abstract: Utilizing mouse precision-cut lung slices with preserved intrapulmonary vessels, we demonstrated a location-dependent structural and contractile regulation of pulmonary arteries in health and on noxious stimulations. For instance, chronic ovalbumin and hypoxic exposure increased pulmonary arterial pressure (PAH) by remodeling intraacinar arterioles to reduce vascular wall compliance while enhancing vasoconstriction in proximal preacinar arteries. These findings suggest region-specific mechanisms and therapeutic targets for pulmonary vascular diseases such as PAH.

Source: American Journal of Physiology-Lung Cellular and Molecular Physiology

DOI: 10.1152/ajplung.00293.2022

Authors: Yan Bai, Guang Li, Laiming Yung, Paul B. Yu, Xingbin Ai

Institutions: Brigham and Women's Hospital, Harvard University, Massachusetts General Hospital, Wuhan University, Renmin Hospital of Wuhan University

Language: English

Topic: Pulmonary Hypertension Research and Treatments

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Heart, Lung, and Blood Institute