Vagal Nerve Stimulation Reduces Ventricular Arrhythmias and Mitigates Adverse Neural Cardiac Remodeling Post–Myocardial Infarction
Year: 2023
Type: article
Abstract: This study sought to evaluate the impact of chronic vagal nerve stimulation (cVNS) on cardiac and extracardiac neural structure/function after myocardial infarction (MI). Groups were control, MI, and MI + cVNS; cVNS was started 2 days post-MI. Terminal experiments were performed 6 weeks post-MI. MI impaired left ventricular mechanical function, evoked anisotropic electrical conduction, increased susceptibility to ventricular tachycardia and fibrillation, and altered neuronal and glial phenotypes in the stellate and dorsal root ganglia, including glial activation. cVNS improved cardiac mechanical function and reduced ventricular tachycardia/ventricular fibrillation post-MI, partly by stabilizing activation/repolarization in the border zone. MI-associated extracardiac neural remodeling, particularly glial activation, was mitigated with cVNS.
Language: English
Subfield: Neurology
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $4,530
Awards: Mechanisms of Cardiac TRPV1 Afferent Remodeling in Ventricular Arrhythmias, The Intrinsic Cardiac Nervous System and Atrial Pacemakers - Implications for Sinus Node Dysfunction, G7012408617, Comprehensive Structural and Functional Mapping of the Mammalian Cardiac Nervous System, Bioelectric monitoring and control of the heart, G8474336050, G900992239
OpenAlex ID: W4379616667