Effects of acute changes in fasting glucose and free fatty acid concentrations on indices of β-cell function and glucose metabolism in subjects without diabetes

Year: 2023

Type: article

Abstract: This experiment studied the effect of changes in overnight concentrations of free fatty acids (FFAs) and glucose on β-cell function and glucose metabolism. In response to elevation of these metabolites, the dynamic component of the β-cell response to glucose was impaired. This suggests that in health overnight hyperglycemia and FFA elevation can deplete preformed insulin granules in the β-cell.

Source: American Journal of Physiology-Endocrinology and Metabolism

DOI: 10.1152/ajpendo.00043.2023

Authors: Daniel Schembri Wismayer, Marcello C. Laurenti, Yilin Song, Aoife M. Egan, Andrew A. Welch, Kent R. Bailey, Claudio Cobelli, Chiara Dalla Man, Michael D. Jensen, Adrian Vella

Institutions: Mayo Clinic, University of Padua

Language: English

Topic: Pancreatic function and diabetes

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Advancing Translational Sciences, Division of Diabetes, Endocrinology, and Metabolic Diseases

OpenAlex ID: W4379617443