Work

Charting a course through the acute promyelocytic leukemia (APL)-like nebula: the enigmatic cousins of APL

Year: 2023

Type: editorial

Abstract: Acute promyelocytic leukemia (APL) is characterized by a constellation of well-established elements, including distinctive morphology, flow cytometry, and clinical presentation.Nowadays, the definitive diagnosis of APL requires the presence of a unique genetic feature, namely the t(15;17)(q24;q21), and/or the presence of the PML-RARα fusion protein(1).The management of this special subtype of acute leukemia relies on a unique approach based on differentiation induction therapy using all-trans retinoic acid (ATRA) and arsenic trioxide (ATO)(2).This dual-targeted therapy has completely revolutionized outcomes in APL.Consequently, relapse or refractory disease in patients treated with ATRA/ATO is extremely unlikely, and practically non-existent.The success of this approach has launched a search for similar types of AML that may benefit from this treatment.

Source: Haematologica

DOI: 10.3324/haematol.2023.283232

Authors: Alexandra Ghiaur, Gabriel Ghiaur

Institutions: Institutul Clinic Fundeni, Johns Hopkins University, Johns Hopkins Medicine

Language: English

Topic: Retinoids in leukemia and cellular processes

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,157

OpenAlex ID: W4379768766

Cites: 10

Cited by: 2

Related to: 10