Decoding the biological properties and transcriptomic landscapes of human natural killer cells derived from bone marrow and umbilical cord blood.
Year: 2023
Type: article
Abstract: memory-like NK cell subset. Furthermore, eUC-NK and eBM-NK manifested multidimensional similarities and diversities in gene expression pattern and genetic spectrum, whereas both eUC-NK and eBM-NK exhibited effective tumor killing capacity. Collectively, we dissected the cellular and transcriptomic signatures of NK cells generated from UC-MNC and BM-MNC, which supplied new literature for further exploring the characteristics of the indicated NK cells and would benefit the clinical application for cancer immunotherapy in future.
Source: PubMed Central
Institutions: Hainan Medical University, Chinese Academy of Sciences, Hefei Institutes of Physical Science, Gansu Provincial Hospital, Xiangnan University, Jiangxi Medical College, Chinese Academy of Medical Sciences & Peking Union Medical College, Institute of Hematology & Blood Diseases Hospital, State Key Laboratory of Experimental Hematology, Union Hospital, First Affiliated Hospital of Kunming Medical University, Anhui Medical University
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
Funders: National Natural Science Foundation of China, Chinese Academy of Sciences, Anhui Medical University, Natural Science Foundation of Fujian Province, Kunming Medical University, Natural Science Foundation of Jiangxi Province, Natural Science Foundation of Hainan Province, Chinese Academy of Medical Sciences, Hainan Medical University, Peking Union Medical College
OpenAlex ID: W4379967242