Figure S7 from Type I Interferon Signaling via the EGR2 Transcriptional Regulator Potentiates CAR T Cell–Intrinsic Dysfunction
Year: 2023
Type: other
Abstract: Gene expression and pathway enrichment analysis of CD4+ T cell clusters. (A) Heatmap showing differentially expressed genes between AAVS1 and EGR2 knockout (KO) CD4+ T-cells. (B-D) Top differentially regulated pathways in CD4+ EGR2 KO compared to AAVS1 KO CAR T-cells. Pathways were explored using: B, GO biological process. C, NCI-Nature Pathway Interaction Database 2015. D, ARCHS4 transcription factor (TF) co-expression.
Authors: In-Young Jung, Robert L. Bartoszek, Andrew J. Rech, Sierra M. Collins, Soon-Keat Ooi, Erik F. Williams, Caitlin R. Hopkins, Vivek Narayan, Naomi B. Haas, Noelle V. Frey, Elizabeth O. Hexner, Donald L. Siegel, Gabriela Plesa, David L. Porter, Adrian Cantu, John K. Everett, Sonia Guedan, Shelley L. Berger, Frederic D. Bushman, Friederike Herbst, Joseph A. Fraietta
Language: English
Topic: CAR-T cell therapy research
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4380052335