Work

Site-specific prolongation of repolarization prevents postmyocardial infarction tachycardia

Year: 2023

Type: article

Abstract: Antiarrhythmic drugs that aim to prolong refractoriness by reducing repolarizing are often used to treat postinfarction ventricular tachycardia (VT). However, these drugs prolong action potential duration throughout the heart and may trigger polymorphic VT by prolonging repolarization in areas where it already is long. Here we investigate whether site-specific prolongation of repolarization in myocardium adjacent to the infarcted myocardium mitigates reentry and prevents postinfarction VT.

Source: Heart Rhythm O2

DOI: 10.1016/j.hroo.2023.06.003

Authors: Ryan P. O’Hara, Veronique M.F. Meijborg, Pouya Jelvehgaran, Jeanne van der Waal, Gerard J.J. Boink, Natalia A. Trayanova, Ruben Coronel, Bastiaan J. Boukens

Institutions: Johns Hopkins University, Amsterdam University Medical Centers, University of Amsterdam, Université de Bordeaux, Inserm, Centre de Recherche Cardio-Thoracique de Bordeaux, Maastricht University Medical Centre, Maastricht University

Language: English

Topic: Cardiac electrophysiology and arrhythmias

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,150

Funders: National Science Foundation, National Sleep Foundation, Health~Holland, Fondation Leducq, ZonMw, Nederlandse Organisatie voor Wetenschappelijk Onderzoek, European Research Council, H2020 European Research Council, Eurostars

Awards: G1522548176, G1865573081, G1978241322, G2015302248, Transcriptional targeting of pacemaker and conduction system gene therapy, G2251132709, G2789485501, G3143272357, G4385979294, Repair of Junctional Atrioventricular Conduction and Impulse Formation, Graduate Research Fellowship Program (GRFP), G5370404108, G5683216848, G5926214448, G7013656764, Repolarization HeterogeneitY imaging for personalised Therapy of Heart ArrhythMia

OpenAlex ID: W4380052761

FWCI: 1.179

Cites: 5

Cited by: 6

Related to: 10