Work

Author response: Molecular basis of ligand-dependent Nurr1-RXRα activation

Year: 2023

Type: peer-review

Abstract: Transcriptional activation of the orphan nuclear receptor Nurr1 by ligands targeting its heterodimer partner retinoid X receptor alpha (RXRα) occurs through a nonclassical pharmacological mechanism involving ligand-binding domain protein-protein interaction inhibition.

DOI: 10.7554/elife.85039.sa2

Authors: Xiaoyu Yu, Jinsai Shang, Douglas J Kojetin

Institutions: Scripps Research Institute, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology

Language: English

Topic: Nuclear Receptors and Signaling

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

Open Access status: gold

OpenAlex ID: W4380368102

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