Circulating lipid profiles are associated with cross-sectional and longitudinal changes of central biomarkers for Alzheimer’s disease
Year: 2023
Type: preprint
Abstract: ABSTRACT Investigating the association of lipidome profiles with central Alzheimer’s disease (AD) biomarkers, including amyloid/tau/neurodegeneration (A/T/N), can provide a holistic view between the lipidome and AD. We performed cross-sectional and longitudinal association analysis of serum lipidome profiles with AD biomarkers in the Alzheimer’s Disease Neuroimaging Initiative cohort (N=1,395). We identified lipid species, classes, and network modules that were significantly associated with cross-sectional and longitudinal changes of A/T/N biomarkers for AD. Notably, we identified the lysoalkylphosphatidylcholine (LPC(O)) as associated with “A/N” biomarkers at baseline at lipid species, class, and module levels. Also, G M3 ganglioside showed significant association with baseline levels and longitudinal changes of the “N” biomarkers at species and class levels. Our study of circulating lipids and central AD biomarkers enabled identification of lipids that play potential roles in the cascade of AD pathogenesis. Our results suggest dysregulation of lipid metabolic pathways as precursors to AD development and progression.
Source: medRxiv
Institutions: Samsung Medical Center, Indiana University Indianapolis, Indiana University School of Medicine, Baker Heart and Diabetes Institute, The University of Melbourne, La Trobe University, Duke University, Helmholtz Munich, Institute of Computational Biology, The University of Texas at San Antonio Health Science Center, Brigham and Women's Hospital, Harvard University, Rosa (United States), German Center for Diabetes Research
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Metabolic Networks and Pathways Predictive of Sex Differences in AD Risk and Responsiveness to Treatment, Metabolic Network Analysis of Biochemical Trajectories in Alzheimer's Disease, Gut Liver Brain Biochemical Axis in Alzheimer's Disease, Alzheimer's Gut Microbiome Project, Metabolic Signatures Underlying Vascular Risk Factors for Alzheimer-type Dementias, Alzheimer's Disease Neuroimaging Initiative, Metabolomic Signatures for Disease Sub-classification and Target Prioritization in AMP-AD, National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)
OpenAlex ID: W4380449822