Work

Renal, but not platelet or skin, extracellular vesicles decrease oxidative stress, enhance nascent peptide synthesis, and protect from ischemic renal injury

Year: 2023

Type: article

Abstract: Acute kidney injury is common and deadly, yet the only approved treatment is dialysis. Thus, a better understanding of injury mechanisms and potential therapies is needed. We found that organ-specific, but not extrarenal, extracellular vesicles improved renal function and structure postischemia when given after renal failure occurred. Oxidative stress was decreased and anti-inflammatory interleukin-10 increased with renal, but not skin or platelet, exosomes. We also propose enhanced nascent peptide synthesis as a novel protective mechanism.

Source: American Journal of Physiology-Renal Physiology

DOI: 10.1152/ajprenal.00321.2022

Authors: Jesus H. Dominguez, Danhui Xie, K. J. Kelly

Institutions: Richard L. Roudebush VA Medical Center, Indiana University Indianapolis, Indiana University School of Medicine, Indiana University – Purdue University Indianapolis

Language: English

Topic: Extracellular vesicles in disease

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: U.S. Department of Veterans Affairs, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, Dialysis Clinics, National Institute of Allergy and Infectious Diseases