Chronic mitochondria antioxidant treatment in older adults alters the circulating milieu to improve endothelial cell function and mitochondrial oxidative stress
Year: 2023
Type: article
Abstract: Chronic supplementation with a mitochondria-targeted antioxidant (MitoQ) improves vascular endothelial function in older adults, but the mechanisms of action are incompletely understood. Here, we show that MitoQ supplementation leads to changes in the circulating milieu (plasma), including reductions in oxidized low-density lipoprotein that enhance nitric oxide production and reduce mitochondrial oxidative stress in endothelial cells. These findings provide new information regarding the mechanisms by which MitoQ improves age-related endothelial dysfunction.
Institution: University of Colorado Boulder
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Mitochondria-targeted antioxidant supplementation for improving age-related vascular dysfunction in older adults, G3201832472, G53487339, G6504526518, G7298477120, Colorado Clinical and Transational Sciences Institute, Mitochondrial-targeted antioxidant supplementation for improving age-related vascular dysfunction in humans
OpenAlex ID: W4380870540