Consumption of aspartame and other artificial sweeteners and risk of cancer in the Spanish multicase‐control study (MCC‐Spain)

Year: 2023

Type: article

Abstract: Use of artificial sweeteners (AS) such as aspartame, cyclamate, saccharin and sucralose is widespread. We evaluated the association of use of aspartame and other AS with cancer. In total 1881 colorectal, 1510 breast, 972 prostate and 351 stomach cancer and 109 chronic lymphocytic leukaemia (CLL) cases and 3629 population controls from the Spanish Multicase-Control (MCC-Spain) study were recruited (2008-2013). The consumption of AS, from table-top sweeteners and artificially sweetened beverages, was assessed through a self-administered and validated food frequency questionnaire (FFQ). Sex-specific quartiles among controls were determined to compare moderate consumers (<third quartile) and high consumers (≥ third quartile) vs non consumers (reference category), distinguishing aspartame-containing products and other AS. Unconditional logistic regression models were used to estimate adjusted OR and 95%CI, and results were stratified by diabetes status. Overall, we found no associations between the consumption of aspartame or other AS and cancer. Among participants with diabetes, high consumption of other AS was associated with colorectal cancer (OR = 1.58, 95% CI 1.05-2.41, P trend = .03) and stomach cancer (OR = 2.27 [0.99-5.44], P trend = .06). High consumption of aspartame, was associated with stomach cancer (OR = 2.04 [0.7-5.4], P trend = .05), while a lower risk was observed for breast cancer (OR = 0.28 [0.08-0.83], P trend = .03). In some cancers, the number of cases in participants with diabetes were small and results should be interpreted cautiously. We did not find associations between use of AS and cancer, but found associations between high consumption of aspartame and other AS and different cancer types among participants with diabetes.

Source: International Journal of Cancer

DOI: 10.1002/ijc.34577

Institutions: Universitat Pompeu Fabra, Instituto de Salud Carlos III, Barcelona Institute for Global Health, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Boston College, Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition, Health Research Institute of the Balearic Islands, Ministry of Health, Municipal Institute for Medical Research, Hospital del Mar Research Institute, Universidad de León, Institut d'Investigació Biomédica de Bellvitge, Institut Català d'Oncologia, Universitat de Barcelona, Universidad de Cantabria, Instituto de Investigación Marqués de Valdecilla, Instituto de Salud Pública de Navarra, Navarre Institute of Health Research, Basque Government, Biogipuzkoa Health Research Institute, Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana, Universidad de Granada, Instituto de Investigación Biosanitaria de Granada, Complejo Hospitalario Universitario de Granada, Universidad de Oviedo, Instituto de Investigación Sanitaria del Principado de Asturias, Universidad de Huelva, Generalitat de Catalunya, Departament de Salut, Institut d'Investigació Biomèdica de Girona, Instituto Murciano de Investigación Biosanitaria, Centro Nacional de Epidemiología

Language: English

Topic: Biochemical Analysis and Sensing Techniques

Subfield: Nutrition and Dietetics

Field: Nursing

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,840

Funders: Centres de Recerca de Catalunya, European Commission, Generalitat de Catalunya, Ministerio de Economía y Competitividad, Generalitat Valenciana, Ministerio de Ciencia e Innovación, Universidad de Oviedo, Junta de Andalucía, Junta de Castilla y León, Fundación Marqués de Valdecilla, Agència de Gestió d'Ajuts Universitaris i de Recerca, Instituto de Salud Carlos III

Awards: G1203044189, G1274129560, G1317564010, G1343860231, G1418927621, G1443676575, G1492351230, G1563087297, G1677669578, G178315305, G1839702727, G1900157527, G2045172656, G2092426522, G2117726266, G2247562131, G2319883305, G2377181310, G2553834064, G2608424811, G2620658983, G2739777946, G2957026379, G3033981070, G3224322550, G3386462639, G3405515844, G3423777635, G3559709381, G3583461342, G3635063837, G3646853989, G3771020718, G3807906117, G3888200106, G43203158, Identificación de marcadores de susceptibilidad genética útiles para el diseño de estrategias personalizadas de cribado, G4502495630, G4505522013, G4561499809, G4600474357, G4623508005, G521056402, G5394670091, G542714222, G5483448829, G556022927, G5578384164, G5675886668, G5881411584, G5890873539, G5893827543, G589846866, G5942132429, G6260981759, G6328075693, G6386293926, G6508629688, Supervivencia de cáncer colorrectal en el proyecto MCC-Spain: Modelos de predicción que integran datos genéticos y clínico-epidemiológicos, G6737142931, G687257720, G7029154051, G7245015376, G7868651054, G7932779895, G7971421345, Integración de big data genéticos y datos clínicos: supervivencia con cáncer de mama en el estudio MCC-Spain, Integración de big data genéticos y datos clínicos: supervivencia y calidad de vida en participantes con cáncer de próstata en el estudio MCC-Spain, G8214743223, Las uñas de los pies como biomarcador de exposición:significado y relación con la incidencia de cáncer, G8759146715, G8835261403, G8931017233, Perfil molecular del envejecimiento en la patogénesis y pronóstico de la leucemia linfática crónica

OpenAlex ID: W4380870578