Work

Application of 4-D ultrasound-derived regional strain and proteomics analysis in Nkx2-5-deficient male mice

Year: 2023

Type: article

Abstract: A multimodal approach using both four-dimensional ultrasound (4DUS) and regional proteomics can help enhance our investigations of murine cardiomyopathy models. We present unique 4DUS-derived strain maps that provide a framework for both cross-sectional and longitudinal analysis of spatiotemporal cardiac function. We further detail and demonstrate an innovative 4DUS-proteomics z-score-based linear regression method, aimed at characterizing relationships between regional cardiac dysfunction and underlying mechanisms of disease.

Source: American Journal of Physiology-Heart and Circulatory Physiology

DOI: 10.1152/ajpheart.00733.2022

Authors: Frederick W. Damen, Daniel P. Gramling, Dorothy Ahlf Wheatcraft, Robert Y. Wilpan, Mauro W. Costa, Craig J. Goergen

Institutions: Purdue University West Lafayette, Indiana University School of Medicine, Jackson Laboratory, Gladstone Institutes

Language: English

Topic: Cardiovascular Function and Risk Factors

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green