Year: 2023
Type: review
Abstract: The potential of cardiac magnetic resonance to improve cardiovascular care and patient management is considerable. Myocardial T1-rho (T1ρ) mapping, in particular, has emerged as a promising biomarker for quantifying myocardial injuries without exogenous contrast agents. Its potential as a contrast-agent-free ("needle-free") and cost-effective diagnostic marker promises high impact both in terms of clinical outcomes and patient comfort. However, myocardial T1ρ mapping is still at a nascent stage of development and the evidence supporting its diagnostic performance and clinical effectiveness is scant, though likely to change with technological improvements. The present review aims at providing a primer on the essentials of myocardial T1ρ mapping, and to describe the current range of clinical applications of the technique to detect and quantify myocardial injuries. We also delineate the important limitations and challenges for clinical deployment, including the urgent need for standardization, the evaluation of bias, and the critical importance of clinical testing. We conclude by outlining technical developments to be expected in the future. If needle-free myocardial T1ρ mapping is shown to improve patient diagnosis and prognosis, and can be effectively integrated in cardiovascular practice, it will fulfill its potential as an essential component of a cardiac magnetic resonance examination.
Institutions: Université de Bordeaux, Inserm, Centre Hospitalier Universitaire Vaudois, Centre Hospitalier Universitaire de Bordeaux, Electrophysiology and Heart Modeling Institute, Hôpital Cardiologique du Haut-Lévêque, Centre de Recherche Cardio-Thoracique de Bordeaux, University of Lausanne, University of Pennsylvania, Centre d'Imagerie BioMedicale
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,790
Funders: National Science Foundation, Institut de France, Equipex, Agence Nationale de la Recherche, Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung, National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of Biomedical Imaging and Bioengineering, HORIZON EUROPE European Research Council
Awards: Plateforme multi-modale d'exploration en cardiologie, G4606764229, G4820431297, G489841048, Black-blood Magnetic Resonance Imaging and Automated AI-based Segmentation for Highly Detailed Characterization of Myocardial Scar, G657782616, A Multidimensional Free-Running Framework for Comprehensive and Quantitative High-Resolution Magnetic Resonance Imaging of the Human Heart and its Vessels, G7240651115, G7861357099, Cardiac MR imaging of hemorrhagic reperfusion injury after myocardial infarction, G9000149996, Center for Advanced Metabolic Imaging in Precision Medicine (CAMIPM)
OpenAlex ID: W4381149767