The relationship between genetic liability, childhood maltreatment, and IQ: findings from the EU-GEI multicentric case–control study
Year: 2023
Type: article
Study design: Observational Study
Abstract: This study investigated if the association between childhood maltreatment and cognition among psychosis patients and community controls was partially accounted for by genetic liability for psychosis. Patients with first-episode psychosis (N = 755) and unaffected controls (N = 1219) from the EU-GEI study were assessed for childhood maltreatment, intelligence quotient (IQ), family history of psychosis (FH), and polygenic risk score for schizophrenia (SZ-PRS). Controlling for FH and SZ-PRS did not attenuate the association between childhood maltreatment and IQ in cases or controls. Findings suggest that these expressions of genetic liability cannot account for the lower levels of cognition found among adults maltreated in childhood.
Authors: Lucia Sideli, Monica Aas, Diego Quattrone, Daniele La Barbera, Caterina La Cascia, Laura Ferraro, Luis Alameda, Eva Velthorst, Giulia Trotta, Giada Tripoli, Adriano Schimmenti, Andrea Fontana, Charlotte Gayer-Anderson, Simona Stilo, Fabio Seminerio, Crocettarachele Sartorio, Giovanna Marrazzo, Antonio Lasalvia, Sarah Tosato, Ilaria Tarricone, Domenico Berardi, Giuseppe D’Andrea, EU-GEI WP2 Group, Silvia Amoretti, Álvaro Andreu-Bernabeu, Grégoire Baudin, Stephanie Beards, Chiara Bonetto, Elena Bonora, Bibiana Cabrera, Angel Carracedo, Thomas Charpeaud, Javier Costas, Doriana Cristofalo, Pedro Cuadrado, Manuel Durán-Cutilla, Aziz Ferchiou, David Fraguas, Nathalie Franke, Flora Frijda, Paz Garcia-Portilla, Javier González Peñas, Kathryn Hubbard, Stéphane Jamain, Estela Jiménez-López, Marion Leboyer, Cloe Llorente, Gonzalo López Montoya, Esther Lorente-Rovira, Covadonga M. Díaz-Caneja, Camila Marcelino Loureiro, Mario Matteis, Elles Messchaart, Ma Dolores Moltó, Gisela Mezquida, Carmen Moreno, Roberto Muratori, Juan Nacher, Mara Parellada, Marta Rapado-Castro, Mirella Ruggeri, Jean-Romain Richard, José Juan Rodríguez Solano, Pilar A. Sáiz, Teresa Sánchez-Gutierrez, Emilio Sánchez, Franck Schürhoff, Marco Seri, Rosana Shuhama, Fabian Termorshuizen, Anne-Marie Tronche, Daniella van Dam, Elsje van der Ven, Celso Arango, Manuel Arrojo, Miguel Bernardo, Julio Bobes, Julio Sanjuán, Jose Luis Santos, Paulo Rossi Menezes, Cristina Marta Del-Ben, Hannah E. Jongsma, Peter B. Jones, James B. Kirkbride, Pierre-Michel Llorca, Andrea Tortelli, Baptiste Pignon, Lieuwe de Haan, Jean-Paul Selten, Jim Van Os, Bart P. Rutten, Richard Bentall, Marta Di Forti, Robin M. Murray, Craig Morgan, Helen L. Fisher
Institutions: Libera Università Maria SS. Assunta, King's College London, University of Palermo, Oslo University Hospital, OsloMet – Oslo Metropolitan University, University of Oslo, Centre Hospitalier Universitaire Vaudois, Centro de Investigación Biomédica en Red de Salud Mental, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío, Universidad de Sevilla, GGZ Noord-Holland-Noord, Università degli Studi di Enna Kore, Istituto S.Anna Crotone, University of Verona, University of Bologna, Hospital General Universitario Gregorio Marañón, Complejo Hospitalario Universitario de Santiago, Instituto de Investigación Sanitaria de Santiago, Instituto de Salud Carlos III, Hospital Clínic de Barcelona, Consorci Institut D'Investigacions Biomediques August Pi I Sunyer, Universitat de Barcelona, Universidad de Oviedo, Instituto de Investigación Sanitaria del Principado de Asturias, Universitat de València, Hospital Virgen de la Luz, Universidade de São Paulo, University of Cambridge, University College London, National Health Service, Université Clermont Auvergne, Cambridgeshire and Peterborough NHS Foundation Trust, Inserm, Fondation FondaMental, Assistance Publique – Hôpitaux de Paris, Amsterdam University Medical Centers, Maastricht University Medical Centre, GGZ Rivierduinen, Utrecht University, University Medical Center Utrecht, University of Sheffield
Language: English
Topic: Child Abuse and Trauma
Subfield: Clinical Psychology
Field: Psychology
Domain: Social Sciences
Open Access status: hybrid
Estimated APC paid: $3,990
Funders: Fundación Alicia Koplowitz, King's College London, European Commission, Fundação de Amparo à Pesquisa do Estado de São Paulo, Ministerio de Ciencia e Innovación, Centro de Investigación Biomédica en Red de Salud Mental, National Institutes of Health, Horizon 2020 Framework Programme, HORIZON EUROPE Framework Programme, Medical Research Council, Economic and Social Research Council, Instituto de Salud Carlos III, European Regional Development Fund, National Institute of Mental Health
Awards: G1033681661, G1332902014, The role of the endocannabinoid system and cannabis use in the expression of psychosis, G1422126554, G1871873595, G1886919625, G1973349908, G2017605187, G2157603779, G2170376007, G2562062227, G2572068296, G3389329809, G3560035619, G3572747598, G3629701755, G3764841371, G3920792168, G4461667574, Estudio integral de variación genética y molecular de una cohorte española de trastornos del espectro autista y diseño de algoritmos de diagnóstico genético y de biotipos terapéuticos. Cohorte ESTEA., G4919021182, G5349269545, G5543596241, G5547416247, G5701184066, Psychiatric Ratings using Intermediate Stratified Markers 2, G5982772783, G5983053349, G6081615879, G6446975009, Autism Innovative Medicine Studies – 2 – Trials, G6972650492, G7050644217, G7070498705, G7094983079, G7131769662, G7291185637, G7336256237, Centre for Society and Mental Health, Enfoque integral y translacional para el diagnóstico genético de TEA: Caracterización clínica, G7636808386, G830610406, European Network of National Schizophrenia Networks Studying Gene-Environment Interactions, G8351277590, G842865865, G8494123976, G8563726104, G8719598721, G8726972595, G8950770007
OpenAlex ID: W4381164099