Evaluation of the anti-cancer study of chloroform seed extract of Datura stramonium on EAC cell lines
Year: 2023
Type: article
Abstract: Including cancer, native medicinal herbs have long been employed for illness prevention and treatment. Herbal supplements are promoted for their wide range of biological benefits, from preventing cancer cell proliferation to boosting the immune system. Datura stramonium L., a member of the Solanaceae family, is a common and easily accessible shrub that may grow to a height of 6 feet on fertile soil and a width of 3 feet in poor soil. The purpose of the current study is to determine whether or not a Chloroform seeds extract of Datura stramonium may inhibit cancer caused by the EAC cell line in albino mice. The collection of plant material and subsequent chloroform extraction using a Soxhlet equipment made this investigation possible. The percentage of cell growth inhibition, tumour weight, packed cell volume, average increase in body weight, change in food intake, mean survival time (MST), percentage increase in life span (% ILS), and viable and non-viable tumour cell count were all significantly different between the 100 mg/kg and 200 mg/kg doses of Datura stramonium in E.A.C. bearing mice. Here there is therapeutic promise for treating illnesses generated by oxidative stress, and the current investigation confirms that Datura stramonium L. is a rich source of considerable natural oxidants with anticancer agents.
Source: Biological Sciences
Authors: Rakesh Sharma, Piyush Seth, Prashant Kumar Dhakad
Language: English
Topic: Medicinal Plant Research
Subfield: Plant Science
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4381295516