Work

Promoter region variant C‐824T in the TH gene modulates the subjective effects of cocaine

Year: 2023

Type: article

Abstract: BACKGROUND AND OBJECTIVES: This study examined how a promoter variant of TH (rs10770141) affects subjective effects of cocaine in 65 nontreatment-seeking individuals with cocaine dependence. METHODS: Participants received cocaine/saline intravenously, and TH genotypes were evaluated. RESULTS: Homozygous individuals for the minor T allele reported greater "good" and "bad" subjective effects to cocaine than those with the major C allele. DISCUSSION AND CONCLUSIONS: TH rs10770141 modulates subjective effects of cocaine in participants with cocaine dependence. SCIENTIFIC SIGNIFICANCE: These results are among the first to indicate that homozygosity of the T allele of rs10770141 modulates greater sensitivity to cocaine.

Source: American Journal on Addictions

DOI: 10.1111/ajad.13444

Authors: Peter K. Bolin, Ellen M. Nielsen, David A. Nielsen, Richard De La Garza

Institutions: Baylor College of Medicine, University of California, Los Angeles

Language: English

Topic: Neurotransmitter Receptor Influence on Behavior

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: National Institute on Drug Abuse