Analysis of the receptor for advanced glycation end-products proteome and protein-protein interactome in PANC-1 cancer cells
Year: 2023
Type: article
Abstract: Background: Pancreatic adenocarcinoma (PA) remains one of the leading causes of cancer related deaths worldwide. The pathogenesis of PA is unclear. However, studies show that the receptor for advanced glycation end-products (RAGE), a member of the immunoglobulin superfamily and pattern recognition receptor, likely plays a role in oncogenesis and cell proliferation. RAGE has multiple functions including amplification and perpetuation of the inflammatory response, protein transport and degradation, maintaining cell polarity, and promoting cell differentiation and division. RAGE may contribute to oncogenesis of PA through dysregulation of ubiquitin and tumor suppressor genes such as p53.
Source: Annals of Pancreatic Cancer
DOI: 10.21037/apc-22-4
Language: English
Subfield: Clinical Biochemistry
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4381325417