FIGURE 2 from Targeting Fatty Acid Reprogramming Suppresses CARM1-expressing Ovarian Cancer
Year: 2023
Type: other
Abstract: CARM1 enhances SCD1 expression by recruiting XBP1s to their promoters independently of its enzymatic activity. A, ChIP-seq track of CARM1 and H3R17me2a in the SCD1 promoter. The arrow indicates the CARM1 and H3R17me2a peak in the promoter region of SCD1 gene. B, ChIP-qPCR analysis for the binding of CARM1 and H3r17me2a or negative control IgG at the SCD1 promoter in control and CARM1 KO A1847 cells. C, CUT&RUN track of XBP1s in the SCD1 promoter. The arrow indicates the XBP1s peak in the promoter region of SCD1 gene. D, ChIP-qPCR analysis for the binding of XBP1s or negative control IgG at the SCD1 promoter in control and CARM1 KO A1847 cells. P value was calculated using a two-tailed Student t test. Data represent mean ± SEM, n = 3 biologically independent experiments.
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4381333289