FIGURE 3 from Targeting Fatty Acid Reprogramming Suppresses CARM1-expressing Ovarian Cancer
Year: 2023
Type: other
Abstract: CARM1 promotes MUFA synthesis. A, Volcano plot illustrating the changes of metabolite levels in wildtype or CARM1 KO A1847 cells detected by LC/MS. Red dots and green dots indicate metabolites significantly upregulated or downregulated in wildtype compared with knockout cells, respectively. Free oleic acid, palmitoleic acid, palmitic acid, and stearic acid were highlighted in blue. P value was calculated using a two-tailed Student t test. B, The level of free oleic acid (18:1), palmitoleic acid (16:1), stearic acid (18:0), and palmitic acid (16:0) as shown in A. C, Changes in total FA profiling for control treated vehicle or SCD1 inhibitor 5 μmol/L CAY10566 for 48 hours, or CARM1 KO A1847 cells. D, The ratio between total oleic acid (18:1) and stearic acid (18:0) in different lipid species determined by lipid profiling in wildtype and CARM1 KO A1847 cells. PC: Phosphatidylcholine; PE: phosphatidylethanolamine; PI: Phosphatidylinositol; PS: Phosphatidylserine; PG: Phosphatidylglycerol; LPC: Lysophosphatidylcholine; PA: Phosphatidic acid; LPE: lysophosphatidylethanolamine; LPS: Lysophosphastidylserine; LPI: Lysophosphatidylinositol; LPA: Lysophosphatidic acid; DG: Diglyceride; ChE: cholesterol ester; and TG:Triglyceride. P value was calculated using a two-tailed Student t test. Data represent mean ± SEM, n = 3 biologically independent experiments unless otherwise stated.
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4381381679