FIGURE 6 from Targeting Fatty Acid Reprogramming Suppresses CARM1-expressing Ovarian Cancer
Year: 2023
Type: other
Abstract: SCD1 inhibition suppresses CARM1-expressing ovarian cancer in vivo. A, Schematic of experimental design for orthotopic xenograft ovarian cancer mouse model using A1847 cells. B and C, Reproductive tracts with tumors from the indicated treatment groups were dissected at the end of treatment (n = 5 mice per group; B). And the weights of tumors dissected from the indicated groups were measured as a surrogate for tumor burden (C). D and E, Same as B and C, but for syngeneic ovarian cancer mouse model using CARM1-expressing UPK10 cells (n = 5 mice per group). F and G, Tumors formed by A1847 cells treated with vehicle control or SCD1 inhibitor CAY10566 were subjected to IHC staining for the cell proliferative marker Ki67 and apoptotic marker cleaved caspase 3 (F), which was quantified on the basis of H score (G). N = 5 mice per group. Scale bars = 100 μm. Data represent mean ± SEM. P values were calculated using two-tailed t test.
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4381382839