Work

The proximity-enabled sulfur fluoride exchange reaction in the protein context

Year: 2023

Type: article

Abstract: usage. These results advanced our understanding of SuFEx reactivity and kinetics in proteins, which is invaluable for ongoing exploration of SuFEx-enabled covalent proteins for basic biological research and creative biotherapeutics.

Source: Chemical Science

DOI: 10.1039/d3sc01921g

Authors: Bingchen Yu, Li Cao, Shanshan Li, Paul C. Klauser, Lei Wang

Institutions: University of California, San Francisco, UCSF Helen Diller Family Comprehensive Cancer Center

Language: English

Topic: Click Chemistry and Applications

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: diamond

Funders: National Institutes of Health, National Cancer Institute, National Institute of General Medical Sciences

Awards: Adding new covalent bonds to proteins in live cells, Covalent Protein Binders for Cancer Research and Therapy, Research Training in Chemistry and Chemical Biology

OpenAlex ID: W4381434442

FWCI: 3.37

Cites: 47

Cited by: 33

Related to: 10