Work

Cigarette smoke alters circRNA expression in human T-cells

Year: 2023

Type: article

Abstract: Circular RNAs (circRNAs), once thought to be a result of splicing errors, have been found to be involved in various molecular processes and in the pathology of various diseases, including cancer and neurodegenerative diseases. Additionally, circRNA expression was found to be altered by lifestyle habits, such as smoking cigarettes. Past studies have revealed that the rate of smoking remains high in people living with human immunodeficiency virus (HIV). In this study, we isolated total RNA from uninfected T-cells that have been exposed to cigarette smoke and compared the expression levels of circRNAs to those of T-cells that were not exposed to cigarette smoke. We identified certain circRNAs that were upregulated or downregulated in T-cells when exposed to cigarette smoke. These data indicate that the study of circRNAs is warranted within the context of HIV.

Source: F1000Research

DOI: 10.12688/f1000research.130430.1

Authors: So Jin Hong, Zhaohao Liao, Kenneth W. Witwer, Ashley E. Russell

Institutions: Johns Hopkins University, Pennsylvania State University

Language: English

Topic: Circular RNAs in diseases

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,350