Year: 2023
Type: article
Study design: Observational Study
Abstract: INTRODUCTION: Growth arrest-specific protein 6 (Gas 6) is a ligand that plays a role in proliferation and migration of cells. For several tumor entities, high levels of Gas 6 are associated with poorer survival. We examined the prognostic role of Gas 6 in renal cell carcinoma (RCC), especially in papillary RCC (pRCC), which is still unclear. METHODS: The patients' sample collection is a joint collaboration of the PANZAR consortium. Patients' medical history and tumor specimens were collected from n = 240 and n = 128 patients with type 1 and 2 pRCC, respectively. Expression of Gas 6 was determined by immunohistochemistry. RESULTS: In total, Gas 6 staining was evaluable in 180 of 240 type 1 and 110 of 128 type 2 pRCC cases. Kaplan-Meier analysis disclosed no significant difference in 5-year overall survival for all pRCC nor either subtype. Also, Gas+ and Gas- groups did not significantly differ in any tumor or patient characteristics. CONCLUSION: Gas 6 was not found to be an independent prognostic marker in pRCC. Future studies are warranted to determine if Gas 6 plays a role as prognostic marker or therapeutic target in pRCC.
Source: Urologia Internationalis
DOI: 10.1159/000529898
Authors: Marie Mikuteit, Stefanie Zschäbitz, Christine Stöhr, Edwin Herrmann, Iris Polifka, Abbas Agaimy, Lutz Trojan, Philipp Ströbel, Frank Becker, Christian Wülfing, Peter Barth, Michael Stöckle, Michael Staehler, Christian Stief, Axel Haferkamp, Markus Hohenfellner, Stefan Duensing, Stephan Macher-Göppinger, Bernd Wullich, Joachim Noldus, Walburgis Brenner, Frederik Roos, Bernhard Walter, Wolfgang Otto, Maximilian Burger, Maximillian Erlmeier, Andres Jan Schrader, Arndt Hartmann, Franziska Erlmeier, Sandra Steffens, German Network Of Kidney Cancer
Institutions: Medizinische Hochschule Hannover, University Hospital Heidelberg, National Center for Tumor Diseases, Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitätsklinikum Erlangen, University Hospital Münster, Universitätsmedizin Göttingen, Universitätsklinikum des Saarlandes, Saarland University, Philipps University of Marburg, Ludwig-Maximilians-Universität München, University Medical Center of the Johannes Gutenberg University Mainz, Universitätsklinik Marien Hospital Herne, Ruhr University Bochum, Johannes Gutenberg University Mainz, University Hospital Frankfurt, University of Regensburg, München Klinik Bogenhausen, München Klinik
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Awards: G1324670248, G2377370727, G6940642009
OpenAlex ID: W4381715464