Work

White Matter Hyperintensities: Complex Predictor of Complex Outcomes

Year: 2023

Type: editorial

Abstract: hite matter hyperintensities (WMHs) pose an enigma in evaluations of brain health and disease.The prevalence of WMH has been estimated to reach 20% to 50% in the general population in midlife, increasing to >90% with advanced age.1,2 Although WMHs can result from a plethora of molecular and cellular abnormalities, they are commonly considered a consequence of cerebral small-vessel disease (cSVD) in the aging brain, frequently associated with hypertension.3,4 Despite associations of WMHs with upstream risk factors, what lays beneath the surface of this radiographic marker of abnormality is thought to be multifactorial in the aging brain, and an active area of research.

Source: Journal of the American Heart Association

DOI: 10.1161/jaha.123.030351

Authors: Nikolaos Karvelas, Fanny M. Elahi

Institutions: Icahn School of Medicine at Mount Sinai, James J. Peters VA Medical Center

Language: English

Topic: Cerebrovascular and genetic disorders

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,700