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FIGURE 4 from A Mendelian Randomization Analysis of 55 Genetically Predicted Metabolic Traits with Breast Cancer Survival Outcomes in the Pathways Study

Year: 2023

Type: other

Abstract: Five forest plots depict the HRs calculated in the ER− group for nominally significant (P < 0.05) survival outcome associations with PGS for five different traits: serum fasting glucose (A), type 2 diabetes (B), AST (C), IGF-1 (D), and total serum protein (E). Each point on the plot represents a test between the PGS-tertile and breast cancer–related survival outcome. Green represents tertile 1. Violet represents tertile 2. Blue represents tertile 3. The y-axis shows the survival outcome, and the x-axis represents the HR. Horizontal lines represent 95% CIs from the Wald test. Associations with P < 0.05, but HR CIs overlapping with one were removed from the plot.

DOI: 10.1158/2767-9764.23560987

Authors: Peter N. Fiorica, Haiyang Sheng, Qianqian Zhu, Janise M. Roh, Cecile A. Laurent, Isaac J. Ergas, Jennifer Delmerico, Marilyn L. Kwan, Lawrence H. Kushi, Christine B. Ambrosone, Song Yao

Language: English

Topic: Genetic Associations and Epidemiology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

OpenAlex ID: W4381740602

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