Association of marijuana, tobacco and alcohol use with estimated glomerular filtration rate in women living with HIV and women without HIV
Year: 2023
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: Marijuana, tobacco and alcohol use are prevalent among people with HIV and may adversely affect kidney function in this population. We determined the association of use of these substances with estimated glomerular filtration rate (eGFR) among women with HIV (WWH) and women without HIV. DESIGN: We undertook a repeated measures study of 1043 WWH and 469 women without HIV within the United States Women's Interagency HIV Study, a multicenter, prospective cohort of HIV-seropositive and HIV-seronegative women. METHODS: We quantified substance exposures using semi-annual questionnaires. Using pooled eGFR data from 2009 to 2019, we used linear regression models with multivariable generalized estimating equations to ascertain associations between current and cumulative substance use exposures with eGFR, adjusting for sociodemographics, chronic kidney disease risk factors and HIV-related factors. RESULTS: Marijuana use of 1-14 days/month versus 0 days/month was associated with 3.34 ml/min per 1.73 m 2 [95% confidence interval (CI) -6.63, -0.06] lower eGFR and marijuana use of >0.02-1.6 marijuana-years versus 0-0.2 marijuana-years was associated with 3.61 ml/min per 1.73 m 2 (95% CI -5.97, -1.24) lower eGFR. Tobacco use was not independently associated with eGFR. Alcohol use of seven or more drinks/week versus no drinks/week was associated with 5.41 ml/min per 1.73 m 2 (95% CI 2.34, 8.48) higher eGFR and alcohol use of >0.7-4.27 drink-years and >4.27 drink-years versus 0-0.7 drink-years were associated with 2.85 ml/min per 1.73 m 2 (95% CI 0.55, 5.15) and 2.26 ml/min per 1.73 m 2 (95% CI 0.33, 4.20) higher eGFR, respectively. CONCLUSION: Among a large cohort of WWH and women without HIV, marijuana use was associated with a lower eGFR while alcohol use was associated with a higher eGFR.
Source: AIDS
Authors: Molly C. Fisher, Donald R. Hoover, Qiuhu Shi, Anjali Sharma, Michelle M. Estrella, Adaora Adimora, Maria Alcaide, Lauren F. Collins, Audrey French, Wei Gao, Susan L. Koletar, Samy I. Mcfarlane, Heather Mckay, Jodie A. Dionne, Frank Palella, Sudipa Sarkar, Amanda Spence, Mallory D. Witt, Michael J. Ross
Institutions: Albert Einstein College of Medicine, Rutgers, The State University of New Jersey, New York Medical College, San Francisco VA Medical Center, University of California, San Francisco, University of North Carolina at Chapel Hill, University of Miami, Emory University, John H. Stroger, Jr. Hospital of Cook County, Cook County Health and Hospitals System, The Ohio State University, State University of New York, SUNY Downstate Health Sciences University, Johns Hopkins University, University of Alabama at Birmingham, Northwestern University, Georgetown University, University of California, Los Angeles, Harbor–UCLA Medical Center
Language: English
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G1400602301, Translational Biomedical Science Training Grant, G1655989834, G1773452051, G183157880, G192128497, G2127051194, G248584506, G2755707676, G2759654445, G2839061624, G30074556, G319781266, G3242306066, G3418878615, G343705321, G483408255, G5431849782, G5747858550, University of Miami Developmental HIV/AIDS Mental Health Research Center (D-ARC), G693265041, Johns Hopkins Institute for Clinical and Translational Research, Clinical and Translational Science Award, University of Pittsburgh MACS/WIHS CCS, MACS/WIHS -CCS, Emory Specialized Center of Research Excellence (SCORE) on Sex Differences, UNC MACS/WIHS Combined Cohort Study Clinical Research Site, Surviving the HIV Epidemic (S/HE) in metropolitan Washington DC - Advancing knowledge through cohort studies, Center for AIDS Research at Emory University, Data Analysis and Coordination Center for the MACS-WIHS Combined Cohort Study, The University of North Carolina Center for AIDS Research, MACS/WIHS Combined Cohort Study: Brooklyn Clinical Research Site (Bklyn CRS), Clinical Research Sites for the MACS/WIHS Combined Cohort Study (MACS/WIHS-CCS) - Baltimore/Wash DC Center, UAB-MISS MACS/WIHS Combined Cohort Study, The University of Miami AIDS Research Center on Mental Health and HIV/AIDS - Center for HIV & Research in Mental Health (CHARM), UCLA Clinical and Translational Science Institute, Clinical Research Sites for the MACS/WIHS Combined Cohort Study (MACS/WIHS-CCS), UAB Center for AIDS Research (CFAR)
OpenAlex ID: W4381839271