Work

Characterization of Two Novel Inhibitors of the Mycobacterium tuberculosis Cytochrome bc 1 Complex

Year: 2023

Type: article

Abstract: Drug-resistant tuberculosis is a global health care threat calling for novel effective treatment options. Here, we report on two novel cytochrome bc 1 inhibitors (MJ-22 and B6) targeting the Mycobacterium tuberculosis respiratory chain with excellent intracellular activities in human macrophages. Both hit compounds revealed very low mutation frequencies and distinct cross-resistance patterns with other advanced cytochrome bc 1 inhibitors.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.00251-23

Authors: Raphael Gries, Michael Dal Molin, Jason Chhen, Edeltraud van Gumpel, Viola Dreyer, Stefan Niemann, Jan Rybniker

Institutions: University of Cologne, German Center for Infection Research, University Hospital Cologne, Research Center Borstel - Leibniz Lung Center

Language: English

Topic: Tuberculosis Research and Epidemiology

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Deutsches Zentrum für Infektionsforschung, European Commission, Nanyang Technological University, Deutsche Forschungsgemeinschaft, Bundesministerium für Bildung und Forschung, Horizon 2020 Framework Programme, Center for Molecular Medicine Cologne, University of Cologne

Awards: G2073929769, G2495613518, G2896909196, G4536697403, G4664210217, G5662841749, EUROPEAN REGIMEN ACCELERATOR FOR TUBERCULOSIS, G6058701156, G8308831470

OpenAlex ID: W4382011060

FWCI: 0.412

Cites: 19

Cited by: 2

Related to: 10