Detection of low-frequency oscillations in neonatal piglets with speckle contrast diffuse correlation tomography
Year: 2023
Type: article
Abstract: Significance: ) with respect to cerebral blood flow (CBF) have shown promise as an indicator of altered neurologic activity in the abnormal brain. Portable optical instruments have evolved to offer a noninvasive alternative for continuous CBF monitoring at the bedside compared with many large neuroimaging modalities. However, their utilization for acquiring LFOs of CBF has only been studied to a limited extent. Aim: We aim to optimize an innovative speckle contrast diffuse correlation tomography (scDCT) system for the detection of LFOs within CBF variations. Approach: The scDCT was optimized to achieve a higher sampling rate and a faster image reconstruction using a moving window 3D reconstruction algorithm with parallel computation. Power spectral density (PSD) analysis was performed to investigate altered LFOs during transient global cerebral ischemia in neonatal piglets. Results: Transient global cerebral ischemia resulted in reductions in both CBF and PSD compared with their baseline values. Conclusions: Spontaneous LFOs, combined with CBF, provide a more comprehensive assay with the potential to clarify pathological mechanisms involved in brain injury. These results support scDCT's inclusion and application in the growing area of LFO analysis and demonstrate its inherent advantage for neurological studies in preclinical and clinical settings, such as neonatal intensive care units.
Source: Journal of Biomedical Optics
Institution: University of Kentucky
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,675
Funders: American Heart Association, University of Kentucky, National Institutes of Health, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute of Mental Health, National Cancer Institute, National Institute of Neurological Disorders and Stroke, National Institute of Biomedical Imaging and Bioengineering, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: Supplement to Prebiotics Intervention to Reduce Alzheimer's Disease Risk via Brain-Gut Axis in an APOE4 Mouse Model, Continuous and Longitudinal Monitoring of Cerebral Blood Flow and Metabolism in Freely Moving Rodents, G4628644001, Mapping Brain Functional Connectivity Using Speckle Contrast Diffuse Correlation Tomography, Perioperative Diffuse Optical Imaging of Tissue Blood Flow and Oxygenation for Optimization of Mastectomy Skin Flap Viability, High-density optical tomography of cerebral blood flow and metabolism in small animals, Assessment of Muscle Vascular Disease with Diffuse Light, G646214437, Implementing a novel, multimodal technique for monitoring cerebrovascular hemodynamics in mice as a diagnostic and prognostic tool for single and repeated mild TBI, Noninvasive Noncontact High-Density Optical Imaging of Neonatal Intraventricular Hemorrhage, A Low-cost Compact Diffuse Speckle Contrast Flow-oximeter for Neonatal Brain Monitoring, Time-resolved laser speckle contrast imaging of resting-state functional connectivity in neonatal brain, Development of a Wearable Fluorescence Imaging Device for IntraoperativeIdentification of Brain Tumors
OpenAlex ID: W4382874342