Work

Endogenous inhibitory mechanisms in asthma

Year: 2023

Type: review

Abstract: Endogenous inhibitory mechanisms promote resolution of inflammation, enhance tissue repair and integrity, and promote homeostasis in the lung. These mechanisms include steroid hormones, regulatory T cells, IL-10, prostaglandin E 2 , prostaglandin I 2 , lipoxins, resolvins, protectins, maresins, glucagon-like peptide-1 receptor, adrenomedullin, nitric oxide, and carbon monoxide. Here we review the most recent literature regarding these endogenous inhibitory mechanisms in asthma, which remain a promising target for the prevention and treatment of asthma.

Source: Journal of Allergy and Clinical Immunology Global

DOI: 10.1016/j.jacig.2023.100135

Authors: Sergio E. Chiarella, Peter J. Barnes

Institutions: Mayo Clinic, Imperial College London

Language: English

Topic: Asthma and respiratory diseases

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,000