FIGURE 3 from Immuno-PET Imaging of CD69 Visualizes T-Cell Activation and Predicts Survival Following Immunotherapy in Murine Glioblastoma
Year: 2023
Type: other
Abstract: CD69 expression increases on TILs following ICI treatment in patients with GBM. A–C, scRNA-seq analysis of sorted CD45+ immune cells (n = 156,766 cells) from 40 patients with GBM: 14 GBM.new, 12 GBM.rec, and 14 GBM.pembro. A, UMAP cell clustering analysis of tumor cell cluster (SOX4; top right), myeloid cell cluster (CD14; middle right), and lymphocyte cluster (CD3D; bottom right). B, UMAP data color-coded by the expression of CD3 (red), CD69 (purple; top), and coexpression (merge) in each group of patients (bottom). C, Dot plot analysis of cells within the lymphocyte cluster; the size of the dots corresponds to the percentage of cells expressing the feature (gene). The color represents the average expression level.
Authors: Michal Nisnboym, Sarah R. Vincze, Zujian Xiong, Chaim T. Sneiderman, Rebecca A. Raphael, Bo Li, Ambika P. Jaswal, ReidAnn E. Sever, Kathryn E. Day, Joseph D. LaToche, Lesley M. Foley, Hanieh Karimi, T. Kevin Hitchens, Sameer Agnihotri, Baoli Hu, Dhivyaa Rajasundaram, Carolyn J. Anderson, Deborah T. Blumenthal, Thomas M. Pearce, Shikhar Uttam, Jessie R. Nedrow, Ashok Panigrahy, Ian F. Pollack, Frank S. Lieberman, Jan Drappatz, Itay Raphael, Wilson B. Edwards, Gary Kohanbash
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4383371305