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A Cyclodiaryliodonium NOX Inhibitor for the Treatment of Pancreatic Cancer via Enzyme‐Activatable Targeted Delivery by Sulfated Glycosaminoglycan Derivatives (Adv. Healthcare Mater. 17/2023)

Year: 2023

Type: article

Abstract: Nanoparticle-Drug Conjugates To combat pancreatic cancer with a dismal prognosis, a self-assembled nanoparticle-drug conjugate is synthesized in article 2203011 by Peng Huang, Shijun Wen, Jiang Yang, and co-workers. Based on chemically-modified sulfated glycosaminoglycan derivatives, a nanoparticle-drug conjugate (NDC) efficiently encapsulates a cyclodiaryliodonium NOX inhibitor from pooled screening, enabling hyaluronidase-activatable release, and facilitates CD44-targeted cellular trafficking to elicit anti-cancer efficacy with a good safety profile.

Source: Advanced Healthcare Materials

DOI: 10.1002/adhm.202370091

Authors: Jiadong Pang, Daqian Zhu, Yang Liu, Dingxin Liu, Chunhua Zhao, Jianeng Zhang, Shengping Li, Zexian Liu, Xiaobing Li, Peng Huang, Shijun Wen, Jiang Yang

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W4383375715

FWCI:

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