Enhanced cellular longevity arising from environmental fluctuations
Year: 2024
Type: article
Abstract: Cellular longevity is regulated by both genetic and environmental factors. However, the interactions of these factors in the context of aging remain largely unclear. Here, we formulate a mathematical model for dynamic glucose modulation of a core gene circuit in yeast aging, which not only guided the design of pro-longevity interventions, but also revealed the theoretical principles underlying these interventions. We introduce the dynamical systems theory to capture two general means for promoting longevity - the creation of a stable fixed point in the "healthy" state of the cell and the dynamic stabilization of the system around this healthy state through environmental oscillations. Guided by the model, we investigate how both of these can be experimentally realized by dynamically modulating environmental glucose levels. The results establish a paradigm for theoretically analyzing the trajectories and perturbations of aging that can be generalized to aging processes in diverse cell types and organisms.
Source: Cell Systems
Institution: University of California San Diego
Language: English
Subfield: Aging
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $9,350
Awards: Dynamically compartmentalized control of gene expression by messenger ribonucleoprotein granules, Network-Driven Dynamics of Replicative Aging, Reprogramming cell-fate decisions through predictive modeling and synthetic biology, Systems biology analysis of RNA-binding protein aggregation during cellular aging
OpenAlex ID: W4401821585