Supplementary Figures 1-7 from Mitophagy Promotes Resistance to BH3 Mimetics in Acute Myeloid Leukemia
Year: 2023
Type: supplementary-materials
Abstract: Supplemental Figure S1 shows the integration of CRISPR/Cas9 loss-of-function screens to identify dependencies and liabilities in BH3-mimetics treatments. Supplemental Figure S2 demonstrates that increased mitochondria-ER interactions contribute to BH3-mimetics resistance. Supplemental Figure S3 shows that mitophagy affects the responsiveness of AML cells to BH3-mimetics. Supplemental Figure S4 reveals that enhanced autophagic clearance of mitochondria as a mechanism of resistance to BH3-mimetics in AML. Supplemental Figure S5 exhibits the synergism between BH3-mimetics and macroautophagy inhibition in human AML. Supplemental Figure S6 shows that deletion of MFN2 or MARCH5 sensitizes AML cells to BH3-mimetics. Supplemental Figure S7 displays that targeting of MFN2 or MARCH5 impairs the process of mitophagy.
Authors: Christina Glytsou, Xufeng Chen, Emmanouil Zacharioudakis, Wafa Al-Santli, Hua Zhou, Bettina Nadorp, Soobeom Lee, Audrey Lasry, Zhengxi Sun, Dimitrios Papaioannou, Michael Cammer, Kun Wang, Tomasz Zal, Malgorzata Anna Zal, Bing Z. Carter, Jo Ishizawa, Raoul Tibes, Aristotelis Tsirigos, Michael Andreeff, Evripidis Gavathiotis, Iannis Aifantis
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4383535779