Work

Strategies for targeted gene delivery using lipid nanoparticles and cell-derived nanovesicles

Year: 2023

Type: review

Abstract: is one of the major hurdles. With the advent of lipid nanoparticles (LNPs) and cell-derived nanovesicles (CDNs), gene delivery holds a very promising future. The targeting of these nanosystems is a prerequisite for effective transfection with minimal side-effects. In this review, we highlight the emerging strategies utilized for the effective targeting of LNPs and CDNs, and we summarize the preparation methodologies for LNPs and CDNs. We have also highlighted the non-ligand targeting of LNPs toward certain organs based on their composition. It is highly expected that continuing the developments in the targeting approaches of LNPs and CDNs for the delivery system will further promote them in clinical translation.

Source: Nanoscale Advances

DOI: 10.1039/d3na00198a

Authors: Dong-yup Lee, Sivashanmugam Amirthalingam, Changyub Lee, Arun Kumar Rajendran, Young-Hyun Ahn, Nathaniel S. Hwang

Institutions: Seoul National University, Institute of Engineering Research

Language: English

Topic: RNA Interference and Gene Delivery

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,962