Year: 2023
Type: conference-paper
Study design: Systematic Review
Abstract: Introduction: Parkinson’s Disease (PD) is a condition in wich the dopamine presence is lowered, causing motor and non-motor symptoms. Constipation of different severities is related to the pathogenesis of PD and is a common affection before the onset of disease. Despite these factors, there is a lack of specific diagnostic tools for the assessment of this symptom in PD, which difficults pathophysiological evaluation of constipation in those with PD or refractory constipation. Objectives: Identify if the findings in anorectal manometry could determine the existence of PD and be included in the examination process of patients with history of constipation. Methods: A systematic literature review was performed through an advanced search on Pubmed engine, in which 21 articles with the descriptors “anorectal” AND “manometry” AND “Parkinson” were selected. Results: Using anorectal manometry, it was detected that patients with PD constipation and functional constipation have dysmotility of the colon and rectum, but there are certain differences in segmental colonic transit time and rectal anal pressure between the groups. Compared with idiopathic constipation, anal sphincter pressures on voluntary squeeze were lower in the PD patients. Furthermore, defecatory dysfunction is found early in the course of the disease additionally to later stages. Conclusion: The use of manometry allows quantitative analysis of anorectal dysfunctions and provides early recognition of pelvic floor dyssynergy and colorectal assessment in PD. Besides, the findings in PD constipation are distinguishable from the findings in other types of constipation and in conditions of normalcy. Therefore, anorectal manometry could be used in the examination of patients with history of constipation in order to facilitate early recognition. In order to incorporate this practice, there is a need for more studies comparing the findings in PD and in other types of constipation.
Language: English
Subfield: Gastroenterology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4383567579