The splicing factor proline and glutamine rich promotes the growth of osteosarcoma via the c-Myc signaling pathway.
Year: 2023
Type: article
Abstract: . Results showed that SFPQ expression was upregulated and correlated with poor prognosis in OS patients. SFPQ overexpression promoted the malignant biological behavior of OS cells, while its knockdown markedly reduced the oncogenic function of OS. Additionally, depletion of SFPQ inhibited OS growth and bone destruction in nude mice. SFPQ overexpression induced malignant biological behaviors, which could be rescued by the depletion of c-Myc. These results suggest an oncogenic role of SFPQ in OS, possibly through the c-Myc signaling pathway.
Source: PubMed
Authors: Lianghao Mao, Pan Jiang, Xuan Lei, Bing Zhang, Xinyu Zhong, Zhengyu Yin, Yongjie Wang, Dapeng Li, Yiming Zhang, Qiping Zheng
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4383709941