Work

USP37 promotes angiogenesis and metastasis in colorectal cancer by facilitating β-catenin stability.

Year: 2023

Type: article

Abstract: experiment suggested that USP37 silencing suppressed the growth and lung metastasis of CRC in nude mice. Interestingly, we found that CTNNB1 (gene coding for β-catenin) level was positively correlated with USP37 level in CRC and USP37 silencing suppressed the expression of β-catenin in CRC cells and xenograft tumor tissues. Further mechanistic studies showed that USP37 could enhance the stability of β-catenin by inhibiting its ubiquitination. Taken together, USP37 acts as an oncogene in CRC, which promotes angiogenesis, metastasis and stemness by enhancing β-catenin stability via inhibiting its ubiquitination. USP37 may be a usefully target in CRC clinical treatment.

Source: PubMed

Authors: Dafeng Tong, Jie Yuan, Zhaoming Wang, Enda Yu, Jifu E

Institutions: Second Military Medical University, Changhai Hospital, Chinese People's Liberation Army

Language: English

Topic: Ubiquitin and proteasome pathways

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4383711326

FWCI: 0.301

Cites: 38

Cited by: 4

Related to: 10