Work

Two Satellite Gene Clusters Enhance Ergot Alkaloid Biosynthesis Capacity of Aspergillus leporis

Year: 2023

Type: article

Abstract: is exceptional in having the genetic capacity to make products from three pathway branches. Moreover, it uses a satellite cluster approach, in which gene products of partial clusters rely on supplementation with a chemical intermediate produced via another gene cluster, to diversify its biosynthetic potential without duplicating all the steps.

Source: Applied and Environmental Microbiology

DOI: 10.1128/aem.00793-23

Authors: Kyle A. Davis, Abigail M. Jones, Daniel G. Panaccione

Institution: West Virginia University

Language: English

Topic: Microbial Natural Products and Biosynthesis

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

Open Access status: green

Funders: U.S. Department of Agriculture, Arnold and Mabel Beckman Foundation, National Institutes of Health, National Institute of General Medical Sciences

Awards: Strategic Reprogramming of the Ergot Alkaloid Pathway, G5641472495