FIGURE 4 from The African-centric P47S Variant of TP53 Confers Immune Dysregulation and Impaired Response to Immune Checkpoint Inhibition
Year: 2023
Type: other
Abstract: Tumor-bearing S47 mice harbor more immunosuppressive splenic immune cell profiles. A, Flow cytometry analyses on splenocytes from TBM for percent positive MDSCs in P47 and S47 mice, respectively. Bar graph on right shows the percent positive MDSCs out of the total CD45+ immune cells. n = 5 mice per group. B, Flow cytometry analyses of indicated activation markers on macrophages in the spleen. Histograms in the top show the mean fluorescent intensity (MFI) of MHC I and histograms in the bottom show MFI of CD86. The red solid line indicates P47 and the filled histogram indicates S47 sample. The bar graphs show quantitative data. n = 5 mice per group. C and D, Expression of CD86 and MHC I by CD11c+CD103+ DCs and CD19+ B cells, respectively, in spleens of TBM, shown as MFI. n = 5 mice per group. Statistics were derived from two-tailed Student t tests. *, P < 0.05.
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4383982433