FIGURE 6 from The African-centric P47S Variant of TP53 Confers Immune Dysregulation and Impaired Response to Immune Checkpoint Inhibition
Year: 2023
Type: other
Abstract: TILs in S47 mice exhibit elevated coexpression of multiple IRs. Tumors and spleens were harvested 21 days after injection of MC38 cells and T cells were analyzed for surface expression of multiple IRs by flow cytometry. Comparison of frequency of CD4+ TILs (A) and CD8+ TILs (B) expressing the LAG3, PD1, TIGIT, or Tim3 IRs between S47 and P47 mice. Comparison of the frequency of IR coexpression profiles in CD4+ TILs (C) and CD8+ TILs (D) between S47 and P47 mice. Bar graphs represent frequencies of specific IR coexpression profiles in the total CD4+ or CD8+ T cell populations derived from tumors, whereas pie charts represent relative frequencies of specific IR profiles in the total CD4+ or CD8+ TIL populations expressing any IR. Pie chart slices represent the average relative frequencies of 5 mice.
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W4383982434