Year: 2023
Type: article
Abstract: Breast cancer is a tumorous growth that develops in mammalian gland-lactating tissue's cell lines.Since aromatase controls how quickly estrogen is produced, it is crucial for treating estrogen-receptor positive breast cancer.The mainstay of treatment continues to be endocrine-based medications, which include aromatase inhibitors and estrogen receptor (ER) modifiers.Several synthetic aromatase inhibitors are now being used in clinical settings to treat hormone-receptor positive breast cancer in postmenopausal women.The hunt for novel aromatase inhibitors, particularly for those, whose activity is promoter-specific and further continues because these treatments could have undesirable side effects.Additionally, scientists have been looking into the prospect of using natural products such as Anti-aromatase (AI).Without causing any adverse side effects, natural compounds are as effective as natural aromatase inhibitors.The anti-aromatase activity of citrus fruits and the compounds isolated from the fruits were studied by various groups.Varied research claims that citrus compounds present in citrus fruits are active against aromatase inhibition.This review was intended to integrate the diverse data obtained from research papers on the anti-aromatase activity of citrus compounds.The collective data that helps the research group to proceed to the next level in converting the compounds into drugs for breast cancer therapy.
Language: English
Subfield: Endocrinology
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W4384068815