Year: 2023
Type: article
Abstract: Circulating skin‐homing cutaneous lymphocyte‐associated antigen (CLA)+ T cells constitute a small subset of human memory T cells involved in several aspects of atopic dermatitis: Staphylococcus aureus related mechanisms, the abnormal Th2 immune response, biomarkers, clinical aspects of the patients, pruritus, and the mechanism of action of targeted therapies. Superantigens, IL‐13, IL‐31, pruritus, CCL17 and early effects on dupilumab‐treated patients have in common that they are associated with the CLA+ T cell mechanisms in atopic dermatitis patients. The function of CLA+ T cells corresponds with the role of T cells belonging to the skin‐associated lymphoid tissue and could be a reason why they reflect different mechanisms of atopic dermatitis and many other T cell mediated skin diseases. The goal of this review is to gather all this translational information of atopic dermatitis pathology.
Source: Allergy
DOI: 10.1111/all.15816
Institutions: Parc Científic de Barcelona, Universitat de Barcelona, Hebrew University of Jerusalem, Shaare Zedek Medical Center, Bikur Cholim Hospital, University of Zurich, Universitat Autònoma de Barcelona, Hospital Del Mar, Hospital del Mar Research Institute, Icahn School of Medicine at Mount Sinai, National Jewish Health
Language: English
Subfield: Dermatology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,900
OpenAlex ID: W4384119923