Work

HIV-1 envelope protein gp120 modulation of glutamate effects on cortical neuronal synapses: implications for HIV-1-associated neuropathogenesis.

Year: 2023

Type: article

Abstract: frequency, decreased numbers of dendritic spines when tested in combination. The observed effects were blocked by either a CXCR4 blocker or an NMDAR antagonist, indicating the involvements of chemokine receptor CXCR4 and NMDARs in gp120 modulation of glutamate effects. These results may imply a potential mechanism for HIV-1-associated neuropathogenesis in the cART era.

Source: PubMed Central

Authors: Jianuo Liu, Jinyan Xie, Debashis Dutta, Huangui Xiong

Institutions: University of Nebraska Medical Center, Second Affiliated Hospital of Nanchang University

Language: English

Topic: Neuroscience and Neuropharmacology Research

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute on Drug Abuse, National Institute of Neurological Disorders and Stroke

Awards: Microglial ion channels and HIV-1-associated dementia, K channel, NLRP3 inflammasome and Meth exacerbation of HAND