Year: 2023
Type: article
Study design: Observational Study
Abstract: Objective: In this study, we aimed to compare heavy metal levels in hair and blood samples of a group of Multiple Sclerosis (MS) patients between MS subtypes.Thus, considering that environmental effects, especially heavy metals, play a role in the formation and progression of various neurodegenerative diseases, we wanted to evaluate whether they could play a role in the progression of MS disease. Materials and Methods:We evaluated 101 MS patients sharing the same geographic area.We performed heavy metal analysis in the blood and hair tissues of these patients.Of these patients, 67 were in the Relapsing Remitting MS (RRMS) group and 34 were in the Progressive MS (PMS) group.When the age of the building they lived in was evaluated, there was no significant difference between the groups (p: 0.06).Results: According to MS subgroups, only iodine (I) element levels in hair samples were higher in the SPMS group compared to the RRMS group (p: 0.015); It was determined that there was no difference in terms of blood samples.When the heavy metal levels in the hair samples of the patients were compared with the reference values, mg (magnesium), ca (calcium), sr (strontium), ba (barium) elements were found to be higher than the reference values.Blood samples didn't differ between groups for MS subtypes.Conclusion: We could not find any articles investigating the effect of heavy metals on MS progression before.In particular, it is necessary to focus on the element Al.
Source: Turkish Journal Of Neurology
Authors: Muhammed Zülfü Yılmaz, Murat Gönen
Institution: Fırat University
Language: English
Subfield: Health, Toxicology and Mutagenesis
Field: Environmental Science
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W4384561128