Work

Association of Cardiovascular Disease in Patients with Mycosis Fungoides and Sézary Syndrome Compared to a Matched Control Cohort

Year: 2023

Type: article

Abstract: Mycosis fungoides/Sézary Syndrome (MF/SS) produces a low-grade chronic inflammatory state that may be associated with an increased risk of cardiovascular events, as seen in other chronic, systemic dermatologic diseases. To assess this association, a retrospective, cross-sectional study was designed in which 421 patients with a biopsy-proven diagnosis of MF/SS were compared to a control cohort of 4210 age-, gender-, and race-matched patients randomly selected from the National Health and Nutritional Evaluation Survey (NHANES) database. The MF/SS cohort had a 14% prevalence of cardiovascular events, which was not statistically different from the control population's prevalence of 13%. In the MF/SS cohort, a multivariable logistic regression model showed that older patients (OR=1.05 for each year of age, 95% CI: 1.02-1.07) and those diagnosed with hypertension (OR=3.40, 95% CI: 1.71-6.75) had a higher risk of a cardiovascular event (p<0.001). Risk factors such as gender, race, smoking, diabetes, and obesity were not significantly associated with cardiovascular events. Findings suggest that in the MF/SS population, advancing age and hypertension are risk factors for cardiovascular events, requiring clinical recognition and management. In addition, further research is needed to understand the complex interplay of how chronic inflammation in MF/SS impacts the immune development of cardiovascular disease.

Source: JID Innovations

DOI: 10.1016/j.xjidi.2023.100219