Work

Development of a bioactive tunable hyaluronic-protein bioconjugate hydrogel for tissue regenerative applications

Year: 2023

Type: article

Abstract: active enzymatic breakdown, compared to HA alone. Additionally, cell count and metabolic activity was significantly higher on HA conjugated fibrinogen compared previous hydrogel formulations. This manuscript discusses the various techniques deployed to characterize our new modified HA fibrinogen chemistry physically, mechanically, and biologically. This work addresses the aforementioned concerns by incorporating controllable degradability and increased cell adhesivity while maintaining incorporation of hyaluronic acid, paving the pathway for use in a variety of applications as a multi-purpose tissue engineering platform.

Source: Journal of Materials Chemistry B

DOI: 10.1039/d2tb02766f