Year: 2023
Type: letter
Abstract: Wang and colleagues 1 argue that our report 2 of lower mutation rates in gene bodies, essential genes and regions marked by H3K4me1 must result from DNA sequencing errors. We appreciate the issues raised by them and by other colleagues 3 . Although we overlooked some sources of errors, these are insufficient to invalidate our conclusions, which are confirmed by more stringent reanalyses of our original data, new analyses restricted to high-confidence germline mutations 4 , and direct demonstration of plant DNA repair proteins being recruited to gene bodies, essential genes and H3K4me1, where they reduce local mutation rates 5 , 6 .
Source: Nature
Authors: J. Grey Monroe, Kevin D. Murray, Wenfei Xian, Thanvi Srikant, Pablo Carbonell-Bejerano, Claude Becker, Mariele Lensink, Moises Exposito-Alonso, Marie Klein, Julia Hildebrandt, Manuela Neumann, Daniel Kliebenstein, Mao-Lun Weng, Eric Imbert, Jon Ågren, Matthew T. Rutter, Charles B. Fenster, Detlef Weigel
Institutions: University of California, Davis, Max Planck Institute for Biology, Carnegie Institution for Science, Carnegie Department of Plant Biology, Stanford University, Westfield State University, Université de Montpellier, Institut des Sciences de l'Evolution de Montpellier, Uppsala University, College of Charleston, South Dakota State University
Language: English
Topic: DNA Repair Mechanisms
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $11,690
OpenAlex ID: W4385270839