FIGURE 1 from Proteogenomic Approaches for the Identification of NF1/Neurofibromin-depleted Estrogen Receptor–positive Breast Cancers for Targeted Treatment
Year: 2023
Type: other
Abstract: CNA complements mRNA for assessing NF1 status in ER+ PDX models. Sample map of 22 ER+ PDXs showing E2-dependent growth, patient disease state of sample used to generate the PDX, presence of recurring ESR1 mutations/fusions, mutation status of TP53, PIK3CA, and NF1. Also shown is NF1 CNAs where “0” represents no change in copy number, “–1” as shallow deletion, and “+1” and “+2” low- and high-level amplification, respectively. Full-length NF1 (NM_001042492) mRNA levels were determined by RNA-seq. The bottom panel shows NF1 exon expression by RNA-seq across NF1 CDS in PDX tumors.
Authors: Beom-Jun Kim, Ze-Yi Zheng, Jonathan T. Lei, Matthew V. Holt, Anran Chen, Jianheng Peng, Diana Fandino, Purba Singh, Hilda Kennedy, Yongchao Dou, María del Rosario Chica-Parrado, Emmanuel Bikorimana, Dan Ye, Yunguan Wang, Ariella B. Hanker, Nada Mohamed, Susan G. Hilsenbeck, Bora Lim, Jaya Ruth Asirvatham, Arun Sreekumar, Bing Zhang, George Miles, Meenakshi Anurag, Matthew J. Ellis, Eric C. Chang
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4385271365